What is what area code is 573?

Area code 573 is a telephone area code in the state of Missouri, serving most of the southeastern part of the state. It was established in 1996 as a split from area code 314. Major cities within the 573 area code include Columbia, Jefferson City, Cape Girardeau, Farmington, and Poplar Bluff. The area code covers a large portion of rural Missouri as well.